GASTRO - DA7349

SUNVOU GASTRO DA7349 SIBO Measurement Device 

1. Device measures Gastro-intestinal Parameters from Exhaled Human Breath. 

2. H2, CH4 and H2S can be measured separately all-in-one device. 

3. Both Online-Direct Connected to Device and Offline-Off-Site-Sampling can be done properly.

4. Biomarkers: H2 + CH4 + H2S + NO + CO 

5. Auto-Calibration 

6. Measurement Range: 0-200 ppb for H2 and 0-75ppb for CH4     

The SIBO breath test measures the levels of certain gases produced by bacteria in the small intestine. The primary gases measured are hydrogen (H2) and methane (CH4). Here's how the test typically works:

• Baseline Breath Sample: Before ingesting any substances, a baseline breath sample is collected. This establishes the normal levels of hydrogen and methane in the individual's breath.

• Ingestion of Substrate: The patient is then given a substrate, typically either lactulose or glucose. These are carbohydrates that are not fully absorbed in the small intestine.

• Bacterial Fermentation: If there is an overgrowth of bacteria in the small intestine, they will ferment the unabsorbed carbohydrates, producing hydrogen and/or methane gas.

• Breath Sample Collection: Over a specific period (usually 2-3 hours), breath samples are collected at regular intervals. The patient breathes into a collection device or bag.

• Gas Analysis: The collected breath samples are then analyzed for the concentrations of hydrogen and methane. Elevated levels of these gases compared to the baseline suggest bacterial overgrowth in the small intestine.

The interpretation of the test results considers the pattern and timing of gas production. Elevated levels of hydrogen early in the testing period suggest bacterial overgrowth in the proximal small intestine, while elevated methane later in the testing period may indicate overgrowth in the distal small intestine.

It's important to note that the choice of substrate (lactulose or glucose) can influence the characteristics of gas production and may vary based on the laboratory or healthcare provider's protocol.

Biomarkers of latest SIBO Testing:

• Hydrogen (H2): When bacteria in the small intestine ferment carbohydrates, they produce hydrogen gas. Elevated levels of hydrogen in the breath after ingestion of a test sugar solution (usually glucose or lactulose) indicate that bacteria are fermenting the sugar in the small intestine, suggesting the presence of SIBO.

• Methane (CH4): Some types of bacteria in the gut can convert hydrogen into methane. High levels of methane in the breath are associated with constipation-predominant symptoms and have been linked to a specific form of bacterial overgrowth involving methanogenic archaea. Methane production is particularly associated with slower transit times through the intestines.

• Hydrogen Sulfide (H2S): Detects Sulfur-Reducing Bacteria: H2S is produced by sulfur-reducing bacteria in the gut. Elevated levels may indicate an overgrowth of these bacteria, which are not detected by standard hydrogen (H2) or methane (CH4) measurements.

• Nitric Oxide (NO): Indicates Inflammatory Activity: NO is a marker of inflammation in the gut. Elevated NO levels can indicate inflammation or immune responses that may be associated with bacterial overgrowth or other gastrointestinal conditions.